In line with the NCBI data, 51.64% (110 out of 213) of the total number of mutations in cases with immunodeficiencies or autoimmunity had CpG mutations mediated by methylation in RAG1 coding sequence compared to 28.86% (28/97) in RAG2 coding sequence (z score = 3.74, p value = 0.0002). This evidence concerns the gene RAG1 and immunodeficiency disease.