Using the TIMER online database, the correlation between FSTL3 expression and immune cell infiltration in tumor tissues was examined and found that the expression of FSTL3 was strongly correlated with B lymphocytes (p < 0.001), CD4 + T lymphocytes (p = 0.009), macrophages (p = 0.01), and neutrophils (p < 0.001) (Supplementary Fig. 2). This evidence concerns the gene CD4 and neoplasm.