Additionally, our study investigated the differences of circulating lymphocyte and CD4+T cell subpopulations, and serum cytokines among early-onset gout, late-onset gout and healthy controls (HCs), and was designed to explore the role of CD4+T cell subpopulations, particularly Th17 and Treg cells and their corresponding serum cytokines in the pathogenesis of gout. Here, CD4 is linked to gout.