Then, the expression of top 5 potential candidate genes (PBX1, CYB5R4, SAR1A, CXCR5, MFSD6) of miR-3074-5p was detected in normal and psoriasis tissues by qPCR; our result revealed that PBX1 was the most upregulated genes in psoriasis tissues compare to normal ones (Fig. 4B). The gene discussed is CXCR5; the disease is psoriasis.