Twenty-four studies investigated ICAM-1 in a total of 1857 RA patients (mean age 52 years, 84% females) and 1476 healthy controls (mean age 48 years, 81% females) [81–86, 88, 89, 91, 92, 94, 97, 100, 101, 103–105, 107, 109, 111, 114–116, 118]. The gene discussed is ICAM1; the disease is rheumatoid arthritis.