Eighteen studies investigated E-selectin in a total of 831 RA patients (mean age 53 years, 78% females) and 720 healthy controls (mean age 50 years, 72% females) [83, 84, 86, 88, 89, 91, 93, 95, 96, 99, 102–104, 106–109, 112]. This evidence concerns the gene SELE and rheumatoid arthritis.