Therefore, given the robust association between RA and atherosclerosis and the potential utility of cell adhesion molecules in the identification of early, subclinical atherosclerosis, we conducted a systematic review and meta-analysis of the circulating concentrations of VCAM-1, ICAM-1, PECAM-1, P-selectin, L-selectin, and E-selectin in RA patients and healthy controls. The gene discussed is ICAM1; the disease is rheumatoid arthritis.