Moreover, significant KEGG pathways were enriched for vascular smooth muscle contraction, cytoskeleton regulation, CAMP signaling, focal adhesion, cGMP-PKG signaling pathway, relaxin signaling pathway, dilated cardiomyopathy, hypertrophic cardiomyopathy, the complement and coagulation cascades, and Renin-angiotensin system. This evidence concerns the gene REN and hypertrophic cardiomyopathy.