While previous articles have investigated the role of the cGAS-STING pathway in BLCA, there are several aspects that make our work novel and distinct: 1-Prognostic Risk Model: We have developed a prognostic risk model using four key genes (IRF3, IKBKB, POLR3G, and CTNNB1) associated with the cGAS-STING pathway. This evidence concerns the gene IRF3 and bladder transitional cell carcinoma.