In summary, we confirmed the significant value of BMRM in predicting the prognosis of PCa patients with the TCGA training set and MSKCC validation set, where five carefully selected DE-BMG genes (THBS2, MMP26, COL4A6, MMP21, and SDC1) may be key molecules in PCa development. This evidence concerns the gene THBS2 and posterior cortical atrophy.