Cdc42 regulates cell polarity, migration, and growth, and contributes to tumor metastasis and poor prognosis.[61] During cardiac fibrosis following myocardial infarction, Cdc42 promotes cardiac fibroblast transdifferentiation into myofibroblasts.[62] Cdc42 activation is important for renal EMT in vitro, although its exact role in tubulointerstitial fibrosis remains elusive.[63] Here, we reported elevated Cdc42 levels in human CKD and mouse fibrotic kidney tissue. This evidence concerns the gene CDC42 and chronic kidney disease.