There was no difference in macrophage response, measured by the density of CD68 immunostaining at 24 h post-stroke between the TKO and WT mice (p = 0.285, Figure 3B), but TKO mice had significantly reduced CD68 immunostaining compared to WT mice 7 days post-stroke (p = 0.001) and 30 days post-stroke (p = 0.0001, Figures 3D, F). Here, CD68 is linked to stroke disorder.