Additionally, we found significant variations in several variables across the NLR tertiles, including sex, BMI, HDL-C, triglycerides, PIR, fasting glucose, glycohemoglobin, insulin use, diabetes drug use, smoking status, CVD, hypertension, ACR, eGFR, MLR, PLR, SII, SIRI, and AISI (all p < 0.05) (Table 1). This evidence concerns the gene INS and hypertensive disorder.