The present study provided evidence that inflammation and oxidative stress correlated with DKD and its distinct phenotypes, since we found that T2DM patients with DKD had significantly higher neutrophil count, and lower lymphocyte count, TBIL, and Hb than those with non-DKD, and neutrophil count was further increased and lymphocyte count, TBIL, and Hb were further decreased in T2DM patients with DKD-non-Alb and DKD stage 3 Alb compared to those with DKD stages 1–2 Alb, and TBIL and Hb were independently significantly associated with the presence of DKD. Here, ALB is linked to type 2 diabetes mellitus.