The imbalance of of several pro-and anti-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), C reactive protein (CRP), neutrophils, lymphocytes, and platelet cells, and pro- and anti-oxidants, such as superoxide dismutase (SOD), malondialdehyde (MDA), and 8-OHdG-8-hydroxy-2′-deoxyguanosine (8-OHdG) have previously been reported to be related to the development of DKD (4, 5, 49, 52, 53). Here, TNF is linked to diabetic kidney disease.