Partial correlation analysis controlling for sex, age, BMI, and duration of diabetes demonstrated that SII was positively associated with apoB/A, FBG, PBG, HbA1c, GE index, METS-IR, neutrophil count, PLT count, serum Cr, urinary ACR, prevalence of low eGFR, albuminuria, DKD, and poor glycaemic, and inversely correlated with TC, HDL-C, lymphocyte count, TBIL, Hb, and eGFR (P<0.01 or P<0.05; Table 2). The gene discussed is APOB; the disease is diabetes mellitus.