Moreover, partial correlation analysis controlling for sex, age, BMI, and duration of diabetes demonstrated that SII was positively associated with apoB/A, FBG, PBG, HbA1c, GE index, poor glycaemic control, METS-IR, and inversely correlated with TC and HDL-C, suggesting that SII might be correlated with metabolic disorders, especially IR, hyperglycemia, and dyslipidaemia, and metabolic disorders might at least partially mediate the relationship between SII and DKD. Here, APOB is linked to diabetic kidney disease.