The results showed that SII was positively associated with age, SBP, PP, apoB/A, FBG, PBG, HbA1c, GE index, neutrophil count, PLT count, serum Cr, urinary ACR, prevalence of low eGFR, albuminuria, DKD, poor glycaemic, and hypertension, and negatively with BMI, drinking, TC, TG, apoA, METS-IR, lymphocyte count, ALT, AST, TBIL, Hb, eGFR, and prevalence of overweight/obesity (P<0.01 or P<0.05; Table 2). The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.