Regarding the effect on steroidogenesis, grape extracts, as well as grapeseed proanthocyanidin B2 improved progesterone and estradiol secretion and this was associated with a higher level of the cholesterol carriers, steroidogenic acute regulatory protein (StAR), cyclic adenosine monophosphate response element-binding protein (CREB), and mitogen-activated protein kinases extracellular signal-regulated kinases 1/2 (MAPK ERK1/2) phosphorylation in both primary luteinized human granulosa cells (hGC) and human tumor granulosa cells (KGN). This evidence concerns the gene MAPK3 and neoplasm.