KLRK1 and B-cell chronic lymphocytic leukemia: In patients with chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and multiple myeloma, NK cells show reduced expression of NKG2D, which in turn is linked to enhanced levels of MICA and MICB, thereby causing anergy in NK cells (Xing and Ferrari de Andrade, 2020).