The GFAP gene (associated with Alexander disease) Sanger sequence analysis and a next-generation sequencing panel of eight genes associated with pyruvate dehydrogenase complex defects (DLAT, DLD, NFUI, PDHA1, PDHB, PDHX, PDK1, and PDK4 genes) did not show any deleterious variants. The gene discussed is DLAT; the disease is Alexander disease.