BTBD10 and amyotrophic lateral sclerosis: In C. elegans, loss of function mutations in BTBD10 homolog btbd-10(tm3335) and btbd-10(tm3607) result in motor deficits and degeneration of touch-receptor and GABAergic motor neurons, creating a possible unique model of juvenile ALS (Table 6) (Nawa et al., 2012).