Mutations in the gene Cu/Zn superoxide dismutase 1 (SOD1) were the first identified genetic cause of fALS and account for approximately 8–23% of familial and 1–4% of sporadic cases without a family history of ALS (Rosen et al., 1993; Muller et al., 2022; Smukowski et al., 2022). Here, SOD1 is linked to amyotrophic lateral sclerosis.