IRF8 and immune system disorder: Based on the results shown in Figures 2A2,B2, 3A1,B1, 4, the discharge episodes caused by lumbar CPG network activation in adult Irf8−/− C57BL/6 mice consisted of discharge episodes caused by activation of the newborn/juvenile and adult lumbar CPG networks, indicating that early-life immunodeficiency due to loss of IRF8 might interfere with the normal development of functions of the lumbar CPG network.