The results indicated that the discharge episodes exerted by activation of the lumbar CPG network in adult Irf8−/− C57BL/6 mice consisted of the discharge episodes exerted by activation of the newborn-juvenile and adult lumbar CPG networks, suggesting the possibility that early-life immunodeficiency due to loss of IRF8 might interfere with the normal development of functions of the lumbar CPG network. This evidence concerns the gene IRF8 and immunodeficiency disease.