Apart from DpC, the analysis of the second generation DpT analogs also identified di-2-pyridylketone 4-ethyl-4-methyl-3-thiosemicarbazone (Dp4e4mT; Fig. 1D) as an agent with considerable promise in terms of its potency and selectivity against tumor cells in vitro and in vivo. This evidence concerns the gene DPT and neoplasm.