Furthermore, we found that the IL-17 signaling pathway, relaxin signaling pathway, cellular senescence, lipid and atherosclerosis, phototransduction, and bladder cancer are up-regulated, while breast cancer, hedgehog signaling pathway, neuroactive ligand-receptor interaction, complement and coagulation cascades, and estrogen signaling pathway are down-regulated (Figure 6C). The gene discussed is IL17A; the disease is atherosclerosis.