JAK2 and central nervous system cancer: TMEM14A plays a role in the development and spread of ovarian cancer, TMEM88 has been documented to induce invasion and metastasis in breast cancer through its interaction with disheveled (Dvl) proteins, TMEM45A and TMEM71 facilitate the proliferation and invasion of glioma cells, and TMEM45B enhances the proliferation, migration, and invasion of gastric cancer cells through the JAK2/STAT3 signaling pathway (45).