The role of hub genes LCK, LAMB1, IGFBP3, and LGALS1 in the pathogenesis and metastasis of acute lymphoblastic leukemia as well as in the development of the nervous system provides evidence to support our hypothesis that there may be a relationship between ALL central nervous system metastasis and neuronal development, which may be arise from locus mutations or gene variants. Here, LGALS1 is linked to acute lymphoblastic leukemia.