Homeostatic iron regulator is a critical iron regulator, and its expression has been reported to correlate with GBM patient survival, although no mechanistic description has yet emerged to explain these observations.22 We therefore investigated the role of HFE in GBM by first determining whether HFE levels in GBM patient tumors differ from those in nontumor brain tissue. The gene discussed is HFE; the disease is glioblastoma.