ARF1 and amyotrophic lateral sclerosis: We further compared the transcriptional profiles of Arf1-ablation-associated microglia with those of microglia in old age [31] (Fig. 4I), ALS [32] (Fig. 4J), DAM [33] (Fig. 4K) and MS [34] (Fig. 4L), and found significant overlap of genes in the microglia of Arf1-ablated mice and the microglia in these disease models.