The activity of Ang-II/angiotensin 1 receptor (AT1R) is subsequently heightened, while the ACE2/Ang 1-7/Mas axis is compromised, resulting in a range of detrimental effects, such as vasoconstriction, aldosterone secretion, hypertrophy, vascular permeability, fibrosis, pro-inflammatory responses, increased production of reactive oxygen species and cardiac remodeling, development of multiple organ dysfunction syndrome (MODS), and gut dysbiosis in individuals affected by COVID-19 [52-56]. This evidence concerns the gene ACE2 and COVID-19.