In tumor microenvironments, neutrophils infiltrate different cancers and express inhibitory immune checkpoints, including ARG1 and PD-1/PDL1, which restrict immune surveillance of malignant cells (Buddhisa et al., 2015; He et al., 2015; Moses and Brandau, 2016; Scapini et al., 2016). Here, CD274 is linked to neoplasm.