Knockdown of SIRT2 in cultured liver cell lines (HepG2 or Huh7) or in HBV infection systems (i.e., HepG2-NTCP or primary human hepatoma) abrogated the levels of cccDNA, pgRNA, sgRNAs, and HBc, core particle assembly, and synthesis of HBV DNA (Wu et al., 2022). The gene discussed is SIRT2; the disease is hepatocellular carcinoma.