Knockdown of SIRT2 in cultured liver cell lines (HepG2 or Huh7) or in HBV infection systems (i.e., HepG2-NTCP or primary human hepatoma) abrogated the levels of cccDNA, pgRNA, sgRNAs, and HBc, core particle assembly, and synthesis of HBV DNA (Wu et al., 2022). This evidence concerns the gene KRT88P and hepatocellular carcinoma.