ITGAX and colitis: Hookworm-derived TIMP-1 was later redesignated as anti-inflammatory protein-1 (AIP-1), and the homologous protein from the human hookworm Necator americanus (Na-AIP-1) reduced acute inflammation in the colon in a mouse model of trinitrobenzoylsulfonic acid-induced colitis in a CD11c+ cell-dependent manner (Ferreira et al., 2017; Buitrago et al., 2021).