STAT3 and colorectal cancer: Certain of these genes have been reported in previous studies, for example, RAB3C is a peripheral membrane protein that is involved in membrane trafficking (vesicle formation) and cell movement (CHANG et al., 2023), and RAB3C overexpression promotes tumor metastasis and is associated with poor prognosis in colorectal cancer, through modulating the ability of cancer cells to release IL-6 through exocytosis and activate the JAK2-STAT3 signaling pathway (CHANG et al., 2017).