HIF1A and central nervous system cancer: The authors revealed that CD73, a critical regulator of local purinergic signaling with an essential role in inflammatory response[103], was mainly expressed in glioblastoma cells with a positive correlation between levels of CD73 and HIF1α expression in the hypoxic tumor regions, where the CD73+ glioma cells co-localize with CD39+ microglia to form a spatially compartmentalized microenvironment to regulate the production of adenosine, a potent immunosuppressive metabolite[102].