A comprehensive study of MGMT promoter activity in glioblastoma cell lines further clarified that dexamethasone, but not TMZ or irradiation, can induce the upregulation of MGMT expression via a SP-1 dependent fashion[148], while not through altering the epigenetic status (i.e., methylation) of the MGMT promoter. The gene discussed is MGMT; the disease is glioblastoma.