Withaferin A, a steroidal lactone isolated from the medicinal plant Ashwagandha [Withania somnifera (L.)Dunal], and Tiliroside, a flavonoid found in the herbs of Tribulus terrestris L., both modulate the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2 pathway in hepatocellular carcinoma. This evidence concerns the gene KEAP1 and hepatocellular carcinoma.