With multiple functions for proliferation, metastasis, and differentiation of cancer cells, the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) signaling pathway is responsible for ferroptosis prevention via sterol regulatory element-binding protein 1 (SREBP1)/stearoyl-CoA desaturase-1 (SCD1)-mediated adipogenesis[26]. Here, MTOR is linked to cancer.