In connection with this, regulatory or tolerogenic DCs increase the levels of colon-infiltrated Tregs and inhibited Th1 and Th17 cell-driven colon inflammation in a Galectin-3:TLR-4:Kynurenine-dependent manner, which demonstrated the importance of both TLR and galectin 3 in the immunosuppressive functions of Tregs (145). Here, LGALS3 is linked to colitis.