Also, DCs from UC patients increased the production of IL-10 and TGF-β and reduced the expression of TLR by using all probiotics except Bb, and DCs from CD patients increased the expression of integrin ß8 and reduced the expression of TLR-4, TLR-9, and IL-12p40 (14). The gene discussed is TGFB1; the disease is Cowden disease.