BECN1 and breast carcinoma: Another study loaded dihydroartemisinin and DOX onto liposomes and found that these nanoparticles, in addition to taking advantage of the EPR effect, downregulated the activity of Bcl-2 and accelerated its dissociation from BECN1, leading to excessive autophagy induced by BECN1 and type II programmed cell death in breast cancer cells.