employed transcriptome sequencing technology to analyze 5 pairs of endometrial cancer tissues and normal endometrial tissues, revealing downregulation of ID1, IGF1, GDF7, SMAD9, TGF-β, and WNT4 expression alongside upregulation of GDF5, INHBA, and ERBB4 in endometrial cancer. The gene discussed is IGF1; the disease is endometrial cancer.