IFNA1 and lactic acidosis: Accordingly, RNA-Seq analysis revealed a glycolytic impairment in SN-mel exposed pDCs that has been confirmed by a reduced glycolytic extracellular acidification, suggesting that glucose deprivation or lactic acidosis by melanoma cells (49) hindered glycolytic metabolism in pDCs (31, 111) and consequently their innate immune functions, such as IFN-α secretion (92, 93).