A set of molecules that are known to modulate the interactions between tumor cells and microenvironment towards a pro-tumoral and immunosuppressive phenotype, such as human lectin CLEC17A (also known as Prolectin) (68, 69), the thrombin receptor FR2 (also known as protease-activated receptor-1, PAR-1) (70–73), the spermine oxidase (SMOX) (74), the transcription factor TOX (75–77) and type II transmembrane glycoprotein ENPP1, were among component loadings inversely related to PC2 as well as directly related to PC3, representing SN-mel conditioning (Supplementary Table S5). This evidence concerns the gene TOX and neoplasm.