A composite panel consisting of six biomarkers, namely osteopontin, soluble human tumor necrosis factor receptor-1, tenascin-C, vascular endothelial growth factor-a, and kidney injury molecule-1 (KIM-1), was developed using LASSO technique in a cohort of 346 normoalbuminic T2DM patients. This evidence concerns the gene HAVCR1 and type 2 diabetes mellitus.