Key studies have revealed that a significant proportion of NSCLC patients harbor EGFR mutations (15, 16), with the common types including EGFR 19 deletions (17, 18), EGFR exon 21 L858R point mutations EGFR exon 20 insertions, T790M-like mutations and P-loop αC-helix compression (PACC) mutations (17–19). Here, EGFR is linked to non-small cell lung carcinoma.