Noteworthy, in the infected group, the coactivation of P2Y2R and P2X7R with UTP at 100 μM and ATP at 500 μM, respectively, induced an adhesion value higher than the effect of each agonist individually, suggesting a potential crosstalk between the signaling of both endothelial receptors in schistosomiasis (Figures 4C, D). The gene discussed is P2RY2; the disease is schistosomiasis.