Our findings in the infected group unveiled a distinct positive cooperation between endothelial P2Y2R and P2X7 signaling, favoring IL-1β release and vascular cell adhesion molecule-1 (VCAM-1)-mediated monocyte adhesion to mesenteric endothelial cells, which might be critical to schistosomiasis mesenteric inflammation. Here, VCAM1 is linked to schistosomiasis.