P2RY2 and schistosomiasis: An interesting finding was that in the infected group, the inhibition of endothelial NF-κB signaling by PDTC not only abolished the effects of the agonists (individually or in combination) but also reduced IL-1β-mediated and basal mononuclear cell adhesion, unveiling a downstream P2Y2R/P2X7R-IL-1β-NF-κB-VCAM-1 signaling in schistosomiasis.