HSPG2 and schistosomiasis: Moreover, in the infected group, endothelial cell pretreatment with the inhibitor of intracellular Ca2+ signaling BAPTA-AM or the PLC inhibitor U73122 prevented the agonist effect and reduced basal leukocyte adhesion (p < 0.001), suggesting that endothelial cell Ca2+ homeostasis is altered by schistosomiasis.