We re-examined the response to ICI treatment in sepsis using PANscore and found that PD-1 was more expressed in the LowPANscore subgroup, while PD-L1, LAG3, TIGIT, TNFRSF9, CD40, IDO1 were expressed in the HighPANscore subgroup (P<0.05, Figure 4E). The gene discussed is IDO1; the disease is Sepsis.