Western blot analysis of CXCR4 downstream signaling inSUDHL6 and U2932 cells showed the ability of IQS-01.01RS to inhibitbasal and CXCL12-induced phosphorylation of ERK1/2 and AKT, and strongdownregulation of the MYC proto-oncogene in ABC- and GCB-DLBCL cells. The gene discussed is CXCL12; the disease is diffuse large B-cell lymphoma.