Moreover, CXCR4 is also expressed on tumorcells, including lymphoma cells, and it is a key receptor for metastaticspread, neoplastic cells survival and tumor angiogenesis.6 Of interest, CXCR4 is upregulated by lymphomacells exposed to PI3K, BTK, and SYK inhibitors, and it can contributeto the lymphoma resistance to these agents.7−9. This evidence concerns the gene BTK and lymphoma.