PIKFYVE and cancer: PI(4,5)P2 production from the PI4P in PM is mediated by the PI4P5K enzymes, in cancer members of PIP5K are shown to regulate cell migration and invasion through its known function on invadopodium formation, where PI(4,5)P2 binding to talin regulate integrin induced extracellular matrix adhesion of cancer cells27,41,50–54.