The relationship between the severity of dysmenorrhea and the expression of COX-2, IFITM3, SFRP4, and WBP2 were compared between the high expression group and the low expression group, and the differences were statistically significant for COX-2 (P = 0.025), IFITM3 (P = 0.033), and SFRP4 (P = 0.020), but no significant difference was detected for WBP2 (P = 0.300; Table 3). The gene discussed is IFITM3; the disease is Dysmenorrhea.