For example, in gastric cancer, knockdown of IFITM3 significantly inhibited the migration, invasion, and proliferation of tumor cells in vitro (Hu et al., 2014), and similar results were observed in oral squamous cell carcinoma, colorectal cancer, breast cancer, glioma, and other tumors (Li et al., 2011; Yang et al., 2013; Zhao et al., 2013; Gan et al., 2019). This evidence concerns the gene IFITM3 and central nervous system cancer.