IL10 and neoplasm: In addition, they can inhibit T cell function by producing regulatory cytokines, such as interleukin 10 (IL-10) and transforming growth factor β (TGF-β) (Noy & Pollard, 2014; Speiser, Ho & Verdeil, 2016), tumor-associated macrophages (TAMs) demonstrate high plasticity, with transcriptional regulation and epitranscriptional reprogramming coordinating specific gene expression patterns and determining phenotypic shifts in TAMs, leading to functional heterogeneity with distinct phenotypes (Locati, Curtale & Mantovani, 2020).