As far as inflammatory response, the regulation of various pathways, such as the NLRP3 inflammasome-mediated Caspase-1/GSDMD pyroptosis pathway and the NF-κB pathway, effectively mitigates chronic prostatitis (Zhao, Yang et al., 2020; Liu, Guo et al., 2023). The gene discussed is NFKB1; the disease is chronic prostatitis.