Sodium-coupled amino acid transporters like SNAT1 (SLC38A1) and SNAT2 (SLC38A2) are capable of increasing net glutamine uptake and have been shown to compensate for ASCT2 deficiency in cancer cells (Bröer et al., 2016; Bröer et al., 2019). The gene discussed is SLC1A5; the disease is cancer.