Numerous studies have already outlined diverse protective effects of vanillic acid and its derivatives against cancer, diabetes, obesity, neurodegenerative, cardiovascular, and hepatic diseases (Anbalagan et al., 2017; Taqvi et al., 2021; Kaur et al., 2022; Hu et al., 2022) suggested that the supplementation of Vanillic acid glucoside can alleviate oxidative stress and reduce the level of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, and TNF-α). The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.