In light of the effects of BSR/5-Loxin® on inflammatory mediators and enzymes in these studies on animal diseases, it is interesting that exogenously added SPMs reduced the levels of pro-inflammatory cytokines like TNF-α and IL-6 as well as of MMPs and nitric oxide in comparable arthritis models (Chiang and Serhan, 2020). This evidence concerns the gene TNF and arthritic joint disease.