The PI3K/AKT signaling can activate the production of endothelial nitric oxide synthase (eNOS) and its release in blood vessels to increase vascular permeability (Zachary, 2003), it is responsible for the expression of Cdc42, Rho, and Rac proteins, which are required for tumor cell invasion and metastasis (Jiang and Liu, 2009; Pang et al., 2011; Graupera and Potente, 2013). The gene discussed is NOS3; the disease is neoplasm.