The levels of Klotho in serum and kidney tissues are decreased in the elderly, as well as in AKI, CKD, diabetes and cardiovascular disease patients with diverse etiologies (Lin et al., 2013; Zhou et al., 2013; Fu and Liu, 2015; Kim et al., 2016; Fountoulakis et al., 2018; Neyra et al., 2020). Here, KL is linked to diabetes mellitus.