In the present study, we demonstrate that Klotho deficiency is a common characteristic feature shared in the elderly and those with various medical conditions such as diabetes, hypertension, CKD and cardiovascular disease (Nagai et al., 2000; Kuro-o, 2011; Navarro-González et al., 2014; Neyra et al., 2020). The gene discussed is KL; the disease is diabetes mellitus.