Inhibition of autophagy in PSCs through reduced IL-6 expression and ECM protein production, Reduction of metastatic PC cells, ERK/MAPK inhibitors, Inhibition of CXCL12/CXCR4 signaling, reduced phosphorylation of ERK and STAT3, downregulation of Hedgehog signaling. This evidence concerns the gene STAT3 and pachyonychia congenita.