Among which, the elevated expression of bromodomain and extraterminal protein 4 (BRD4) is closely associated with the epigenetic regulation of c‐Myc and PD‐L1, and c‐Myc is an important transcription factor in colorectal cancer glycolysis.[9] However, such a sophisticated and synergistic mechanism is rarely investigated for chemotherapy‐enabled colorectal cancer immunotherapy. The gene discussed is CD274; the disease is colorectal cancer.