Effective medication strategies with long‐lasting benefits are desired in consideration of its characteristics of easy metastasis.[1] As we know, the upregulation of programmed death ligand 1 (PD‐L1) enables colorectal cancer cells to escape from immune elimination, but immune checkpoint blockade (ICB) can reverse the immune inhibitory signals to provoke durable antitumor immunity.[2] Beneficially, ICB can reinvigorate cytotoxic T lymphocytes (CTLs) to secrete antitumor cytokines (perforin, granzyme, interferon γ, et al). This evidence concerns the gene CD274 and colorectal cancer.