Those who without information of eczema (n = 536), Zn intake (n = 816), serum IgE level (n = 571), cotinine (n = 454), family educational background (n = 84), exposure to environmental tobacco smoke (n = 8), insurance (n = 9), and hay fever (n = 3) were excluded. The gene discussed is IGHE; the disease is seasonal allergic rhinitis.